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Ellitron Computing provides information and papers on immunoassays, as well as software
for the biostatistical analysis of data from immunoassays, especially limiting dilution
assays.
For a comprehensive history of limiting dilution assays and analysis, please refer
to the review chapter
available on the
Papers Page. However, I would like to pay tribute here to some of the original
investigators who published papers on limiting dilution assays:
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E B Phelps, 1908
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LDA of bacteria
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A Cunningham, 1915
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LDA of protozoa
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M H McCrady, 1915
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binomial model for LDA
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M Greenwood and G U Yule, 1917
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Poisson model for LDA
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H Clark, 1927
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LDA of viruses
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H B Hewitt, 1958
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LDA of tumor cells
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T Makinodan and J F Albright, 1962
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LDA of immunocompetent cells
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E Barbarese et al, 1983
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LDA of neurocompetent cells
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I would also like to acknowledge and express my thanks and appreciation to those
investigators who contributed, either directly or indirectly, to the research reported in
the papers available from this website. I have listed them here, together with their
current affiliations, in chronological order of my initial contact with them:
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K G Mann
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University Vermont,
College Medicine,
Department Biochemistry
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| F C McDuffie
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Emeritus,
Mayo Clinic College Medicine,
Division Rheumatology
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J C Cerottini
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Ludwig Institute Cancer Research,
Lausanne Branch
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H R MacDonald
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Ludwig Institute Cancer Research,
Lausanne Branch
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H Engers
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World Health Organization,
Tropical Disease Research
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D J Finney
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Emeritus,
University Edinburgh,
School Mathematics
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C Carnaud
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Universite Pierre Marie Curie,
INSERM,
IFR65 IRSSA
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C B Begg
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Memorial Sloan-Kettering Cancer Center,
Dept Epidemiology/Biostatistics
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| W F Taylor
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Emeritus,
Mayo Clinic College Medicine,
Division Biostatistics
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E C Lattime
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UMDNJ,
Robert Wood Johnson Medical School,
Division Surgical Oncology
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J Ware
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Harvard University,
School Public Health,
Department Biostatistics
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C S Reiss
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New York University,
Department Biology
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R A Miller
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University Michigan,
Department Pathology,
Geriatrics Center
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R G Titus
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CSU,
College Veterinary Med Biomed Sci,
Dept Microbiol/Immunol/Pathol
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...with apologies for any of my memory deficits and unintended omissions or mistakes which I will be happy to correct.
I also wish to express a special thanks to Ken Mann who taught me the importance of rigorous analytic methods
in experimental science, and to Rich Titus who kept interest in ELIDA Software alive during the years when the internet
and web was not what it is today, ie, when it was a much more onerous chore to distribute copies of software on
floppy disks.
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